Hi, we have successfully managed to get the driver work on Windows 10.
Please open the device manager (while the PLC is disconnected from the computer).
Expand both "Network Adapters" and "Ports (COM & LPT)"
Now, connect the PLC. Was the PLC added to the "Network Adapters" as "Unitronics Unistream USB Ethernet/RNDIS Gadget", or was a Serial Com Port added to the Ports?
Windows 10 might recognize the PLC as a serial port, which in this case, the driver should be browsed specifically, while the signed drivers enforcement is turned off.