Please read this https://unitronicsplc.com/Download/SoftwareHelp/U90LadderKnowledgebase/Communications/Direct_Communications-_PC_to_PLC.htm You can see that jazz PRG use pin 1 and 6 for PWR.   Maybe USB-to-serial adapter do not offer correct power supply to Jazz PRG.   The connection may start and disappear due to insufficient power to the adapter. USB-to-serial adapter usually uses a low power converter based on the capacitors to generate output signals, so it may not be a
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